Magnolol is a biologically active compound, isolated from the Chinese herb Magnolia, that regulates antiproliferative, anticancer, antiangiogenic and antimetastatic activities.We found that magnolol sensitizes TRAIL-induced apoptotic cell death via upregulation of DR5 and downregulation of cellular FLICE-inhibitory protein (c-FLIP) and Mcl-1 ESTER-
Recent breakthroughs in single-cell sequencing, advancements in cellular and tissue imaging techniques, innovations in cell lineage tracing, and insights into the epigenome collectively illuminate the enigmatic landscape of alveolar macrophages in the lung under homeostasis and disease conditions.Our current knowledge Outdoor Coffee Table reveals t
ABSTRACT The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy.The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat.However, for such a strategy to be effective, the evolution of phage resistance must be s
The research was based on fifteen etymological and explanatory dictionaries of the Russian language and featured the motivating signs of the macroconcept uchitel / uchenik (teacher / pupil).Conceptual, descriptive, and interpretive analyses revealed 46 motivating signs, which indicates the long history of the macroconcept.The signs constituted thir